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Elderberry Confirmed as Immunity Booster
Analysis by Dr. Joseph MercolaFact Checked
elderberries confirmed as immunity booster
STORY AT-A-GLANCE
Research found compounds in black elderberry (Sambucus
nigra) could directly inhibit viral entry into cells and subsequent
replication, in part attributed to the anthocyanidin responsible for the vivid
purple coloring of the fruit
Flu is caused by the influenza virus, triggering fever,
cough, sore throat, muscle aches and fatigue lasting five to seven days; you
may be infectious up to 24 hours before your first symptom
Flu vaccines are produced before the first seasonal
outbreak, so manufacturers can only estimate which viruses to include in the
vaccine; according to the Centers for Disease Control and Prevention, the flu
vaccine has been less than 50% effective more than half the time in the past 14
years
Elderberries are high in phytonutrients but must be cooked
thoroughly before use as they contain a poisonous cyanide-producing chemical.
In addition to elderberry, using quercetin during a viral illness may reduce
the length of your illness
Elderberries have been used for hundreds of years for their
health benefits. Many believe the high number of antioxidants in the berries
contribute to its ability to fight the flu, support the immune system and
relieve colds. Elderberries are the fruit of the Sambucus tree, the most common
of which is Sambucus nigra.1
Recipes using elderberries for medicinal purposes have been recorded dating back to ancient Egypt, where they were used as a skin and burn potion.3 Historians generally credit Hippocrates as the first physician to use it, who described the elderberry as his "medicine chest."4
Herbal products and folk medicines have been used for centuries to combat a range of ailments, sometimes to the embarrassment of modern scientists. A chemical and biomolecular engineering research team from the University of Sydney focused a new study5 on the phytochemicals and compounds found in elderberries that may positively affect health.
Elderberry Extract May Minimize Flu Symptoms
Although there are several different types of elderberry
plants, the most commonly known and studied is the Sambucus nigra. Supplements
are available as syrup, gummies, lozenges, pills and tea, and were believed to
work by supplying antioxidants and supporting the natural immune support
response.6
In the current study,7 researchers found compounds in the elderberry could directly inhibit the flu virus's entrance into cells and subsequent replication. Flu-fighting properties had been observed in previous studies, but this group examined the actual mechanism the phytochemicals used to combat the influenza infection.
The researchers used commercially cultivated elderberries, which were used for elderberry juice serum. They applied this to cells before, during and after they had infected them with the influenza virus. As expected, the juice was effective at stopping the virus from infecting the cells.8
However, they were surprised to find the juice also effectively inhibited replication after the cells had been infected with the virus. The authors found this significant since blocking the virus at several stages increases the potential it may inhibit infection. Study author Fariba Dehghani, Ph.D., commented:9
"In addition to that, we identified that the elderberry solution also stimulated the cells to release certain cytokines, which are chemical messengers that the immune system uses for communication between different cell types to coordinate a more efficient response against the invading pathogen."
The team also discovered the antiviral activity was in part attributed to the anthocyanidin compounds, phytonutrients responsible for the vivid purple coloring in the fruit. The study supported the results of a previous study10 in which adults suffering from flu-like symptoms who took elderberry syrup had their illnesses clear on average four days sooner than those who took a placebo syrup.
Another study11 tested the effectiveness of an elderberry product on 312 overseas air travelers. The researchers found there was not a statistically significant difference in the number who acquired a cold, but those taking the syrup had a shorter duration and less severe cold symptoms than the control group.
Key Facts About the Flu
Influenza, commonly called flu, is a contagious respiratory
illness that may cause mild to severe symptoms. Although some of the symptoms
are similar, flu is different from a cold caused by a separate set of viruses.
According to the Center for Disease Control and Prevention (CDC),12 flu
symptoms may occur rapidly and include:
Fever or feeling feverish and experiencing chills
Muscle or body aches
Headaches
Sore throat
Cough
Runny or stuffy nose
Fatigue
Some may experience vomiting and diarrhea, although this is more common in children than adults. Most think of flu season occurring between October and May when millions across the U.S. contract the virus.13 However, while this is the most common time, the virus may spread at any time during the year.
Wintertime flu is more common as the virus lives longer indoors during the winter months when the air is less humid than it is outside. During the winter, we also tend to spend more time indoors and have closer contact with others, making it easier for the virus to spread.14
The virus spreads through the air after an individual who is infected sneezes, coughs or speaks. Sometimes it may be passed through an object that's been touched or coughed on. An individual may touch the contaminated item and then touch their nose or mouth, at which time the virus enters their system.
While there are more than 100 different viruses known to trigger cold symptoms, there are only four influenza viruses.16,17 Scientists have named them Types A, B, C and D.
Type A flu viruses may be found in different animals as well as humans, including ducks, chickens, horses, pigs and seals.18 Type B viruses only affect people. Type C viruses cause mild respiratory symptoms while Type A and B are responsible for seasonal outbreaks. Type D is associated with cattle and so far has not been known to infect humans.19
The Flu Vaccine Will Always Struggle To Be Effective
Each year the influenza virus changes slightly, which the
CDC describes as drift or shift.20 In some years, this means flu symptoms may
be mild as your body was exposed to a similar virus and has produced antibodies
to fight the infection. Approximately every 10 years to 40 years the virus undergoes
a major change and more people get severe symptoms and a pandemic may arise.21
Vaccines are produced before flu season begins, so scientists must resort to an educated guess as to how the virus may have changed from the year before to adjust their vaccine for the current year.
According to the CDC, three production technologies have been approved by the U.S. Food and Drug Administration (FDA), including egg-based vaccines, cell-based vaccines and recombinant vaccines.22
Each is made by manufacturers in the private sector. Over the last 14 seasons, CDC data show the vaccine is less than 50% effective more than half the time.23 As just one example, the CDC estimated the overall effectiveness for the 2017 flu vaccine was a modest 38%.
Steer Clear of Drugs to Treat the Flu
Should you or your child be infected with the influenza
virus, your doctor or pediatrician may recommend Tamiflu.24 However, it's
important to note this antiviral drug shortens flu symptoms by less than 17
hours,25 does not reduce viral spread, and does not lessen your risk of
complications such as pneumonia.26
A review of the literature by the Cochrane group also warns that the health risks associated with Tamiflu could far outweigh the benefits.27 Many pharmaceutical drugs come with side effects, and Tamiflu is not exempt. Risks may include seizures, brain infections, psychosis and other neuropsychiatric problems.
A 2015 study28 reported how a 22-year-old man experienced auditory hallucinations, memory deterioration, mood swings, suicidal feelings and insomnia after taking the drug. An ABC News story29 described how a 6-year-old girl started hallucinating and attempted to jump out a second-story window after taking Tamiflu.
Another study30 found more than half of all children suffered side effects from Tamiflu. A journalist in the Atlantic noted,31 "The only people helped by the proven-to-be-ineffective drug are its manufacturers." A 2013 Forbes32 article spelled out several flaws in the science behind Tamiflu, and how the benefits were overstated.
While researchers found elderberry products could reduce
cold and flu symptoms without the side effects associated with the flu shot or
antiviral medications, the berries may also have additional benefits. If you
choose to pick your own elderberries, they may be used to make juice, wine,
extracts, syrups and jams.34
When picking, seek out blue, dark purple or black fruit as only these varieties may be eaten.35 It is crucial that they are completely ripened and you cook them thoroughly before ingesting since the raw berries are poisonous, containing a cyanide-producing chemical.36In addition to the flu fighting benefits, elderberries may also:
Promote detoxification37
Reduce cardiovascular disease38
Promote wound healing39
Soften skin and treat acne40
Soothe sunburns41
Promote the healing of sprains and bruises42
Naturally Support Your Immune System
Your immune system is your first line of defense against
infections, so the most effective method of preventing illness is support your
immune system. Your diet and other lifestyle factors are foundational to immune
function. Nutrition may be the most vital component in maintaining — or gaining
— a healthy immune system.
Successfully running the gauntlet of flu season may be simply a matter of keeping your immune system boosted by applying a few key health strategies. Aside from school and work, other points at which your immune system might be compromised include during travel, and when you are sleep deprived or stressed out.
1 Medical News Today, October 9, 2018
2 The Herb Society of America, 2013
3 Journal of Dietary Supplements January 2014
4 BMC Complement Altern Med 2011; 11: 16
5, 7 Journal of Functional Food, 2019;54:353
6 Discover. What Is Elderberry Good For? May 2, 2022
8, 9 Science Daily, April 23, 2019
10 Journal of International Medical Research,
2004;32(2):132
11 Nutrients, 2016;8(4):182
12 Center for Disease Control and Prevention, Key Facts
About Influenza
13 Kids Health, Flu Facts
14 CDC. How Flu Spreads
15 Harvard Health Publishing, How Long Does the Flu Last?
16, 19 Centers for Disease Control and Prevention, Types of
Influenza Viruses September 27, 2017
17 Stat Pearls, Influenza February 18, 2019
18 Centers for Disease Control and Prevention, Transmission
… Between Animals and People, February 10, 2015
20 Centers for Disease Control and Prevention, How the Flu
Virus Changes
21 CDC Pink Book May 16, 2018
22 Center for Disease Control and Prevention, How Influenza
Vaccines are Made
23 CDC, February 15, 2018. Seasonal Influenza Vaccine
Effectiveness, 2005-2018
24 Mayo Clinic, Influenza (Flu) April 11, 2019
25, 26 BMJ 2014;348:g2545
27 Cochrane Database of Systematic Reviews 2014, Issue 4.
Art. No.: CD008965
28 Clinical Psychopharmacology and Neuroscience, 2015; 13(2):
209–211
29 ABC News, January 16, 2018
30 Eurosurveillance July 2009; 14(30)
31 The Atlantic February 19, 2013
32 Forbes, January 8, 2013
33 Center for Disease Control and Prevention, Preventive
Steps
34 Utah State University Extension, Elderberry in the
Garden
35 The Spruce, January 9, 2019
36 Molecules. 2021 Mar; 26(5): 1384
37 The Alchemists Kitchen, Elderberry: Queen of Herbs
38 International Journal of Molecular Sciences,
2017;18(3):584
39 Cure Joy, September 21, 2017
40 American Nutrition Association, August 6, 2017
41 Lily Farm Fresh Skin Care, Elderberry, A Medicinal Plant
42 Medscape, Elderberry
43 Ther Adv Psychopharmacol. 2012 Aug; 2(4): 131–138
From comments section:
Elderberry extracts prevented GSH depletion, ROS production, and DNA fragmentation Bioactivity tests revealed that elderberry juice was an extremely potent agent in the NO free radical scavenging process (53.06 g TE per L of juice), while in reducing excessive enzyme activity, the The best result was achieved in the inhibition of the enzyme tyrosinase (54.70 mg KAE per g of juice).
www.sciencedirect.com/.../S1756464614002400 (2015)
www.babybearsfarm.com/uploads/7/1/2/5/71259929/charlebois284-292.pdf (2007)
pubs.rsc.org/.../d0ra09129d (2020)
bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-02.. (2021)
link.springer.com/.../s11696-021-01862-x (2022)
pubs.acs.org/.../acs.jafc.2c00010 (2022)
www.sciencedirect.com/.../S2590157522002358 (2022).
Immunodaat, a proprietary botanical extract, contains standardized elderberry extract (Sambucus Nigra L.). Elderberry is used as an immunity enhancer for the prevention and treatment of various respiratory diseases and as an antioxidant. A prospective, multicenter, randomized, comparative, open-label clinical study was conducted in 74 subjects who recovered from post-COVID-19 symptoms of mild to moderate COVID-19 in the past.
The study concludes that the use of Immunodaat for 30 days helped normalize physical and mental symptoms that occurred due to Post COVID and prolonged COVID. Immunodaat can be considered as a safe and effective natural ingredient in the management of Post COVID-19 or prolonged COVID condition. www.medrxiv.org/.../2022.10.04.22280680v2 (2022)
3 recommendations to rescue patients from COVID-19 infection 1) People who have been exposed to nicotine prior to their exposure to the virus are "set" to be at increased risk because nicotine can directly affect the virus's putative receptor (ACE2) and lead to detrimental signaling. in the epithelial cells of the lung. Furthermore, several cytokines, including IL-2, IL-6, and TNF-, which are induced by smoking, could trigger a "cytokine storm" in COVID-19. febs.onlinelibrary.wiley.com/.../febs.15303 (2020) 2) Mouth spray as recommended by Dr. Mercola.
Blocking virus entry is a potential therapeutic target, direct virus clearance in the throat by betadine oral or nasal spray could be more effective than angiotensin receptor 2 (AR2) receptor downregulation 3) The use of elderberry supplements may be effective in an early course of the disease. Although not tested in coronavirus, elderberry supplements were shown to be effective in cold and influenza by a randomized, double-blind, placebo-controlled study and meta-analysis. Currently, since elderberry supplements can be purchased by anyone without a prescription as an over-the-counter medication, if it does not cause any significant harm, there is no reason not to use it and it can be applied early in the course of the disease.
Although there have been some reports of some cytokines being increased by elderberry supplements, elderberry supplements also have various types of other effects. In addition, we should also refer to the evidence-based systematic review of elderberry and elderflower by the Natural Standard Research Collaboration, which could be applied to the current COVID-19 pandemic.
At this point, we should be able to guide the use of these elderberry supplements to the general population or patients with COVID-19 as follows: “Elderberry supplements can be used in people with COVID-19 in an early course of the disease , if understanding the previous efficacy of these and the possible adverse effects”. alkalinediet.com/.../ElderberryAntiViral.pdf (2021)
www.researchgate.net/profile/Ethan-Basch/publication/259696401_An_Evid.. the-Natural-Standard-Research-Collaboration.pdf --- ELDERBERRIES AS A POTENTIAL SUPPLEMENT TO IMPROVE VASCULAR FUNCTION IN A SARS-COV-2 ENVIRONMENT According to the literature, anthocyanins, a major subgroup of flavonoid polyphenols found in berries, have been well-investigated for their vascular-protective properties, as well as the prevention of cardiovascular disease (CVD)-related deaths.
Elderberries have previously been used as a natural remedy for the treatment of colds, flu, and consequently cardiovascular health due to a high content of cyanidin-3-glucoside (C3G), one of the main anthocyanins found in the human diet. The literature reported many studies showing that EE has both antiviral and vascular protective properties that need to be further investigated as a nutritional component used against the indirect effect of SARS-CoV-2 on vascular function. onlinelibrary.wiley.com/.../jfbc.14091 (2022)